International Journal of Pharmaceutical Sciences and Drug Analysis
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P-ISSN: 2788-9246, E-ISSN: 2788-9254
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International Journal of Pharmaceutical Sciences and Drug Analysis

2021, Vol. 1, Issue 1, Part A

Ultrasound-assisted green synthesis of 2,4-thiazolidinedione and diaryl substituted pyrazolylthiazolidinediones catalyzed by β-alanine


Author(s): Mamdouh FA Mohamed, Marwa A Aziz and Gamal El-Din A Abuo-Rahma

Abstract: A new method was carried out for the synthesis of 2,4-thiazolidinedione 3 by heating thiourea and chloroacetyl chloride in water under ultrasonic irradiation. Moreover, a rapid and green method has been developed for the synthesis of a series of diaryl substituted pyrazolyl-2,4-thiazolidinediones 8a-g through the reaction of appropriate pyrazolecarboxaldehydes 7a-g with 2,4-thiazolidinedione 3 using β-alanine as a catalyst. All compounds were characterized by their reported melting points, FT-IR, 1H and 13C NMR spectroscopy in addition to elemental analysis. This new synthetic method has advantages of being gives a product with high purity, good yield, and short reaction times when compared to the previously reported methods.

Pages: 18-25 | Views: 1062 | Downloads: 457

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How to cite this article:
Mamdouh FA Mohamed, Marwa A Aziz, Gamal El-Din A Abuo-Rahma. Ultrasound-assisted green synthesis of 2,4-thiazolidinedione and diaryl substituted pyrazolylthiazolidinediones catalyzed by β-alanine. Int J Pharm Sci Drug Anal 2021;1(1):18-25.
International Journal of Pharmaceutical Sciences and Drug Analysis