Author(s): Khaled Rashed

Abstract: Amaryllidaceae alkaloids (AA), have attracted considerable attention due to their interesting pharmacological activities. One of them, galantamine, is already used in the therapy of Alzheimer’s disease as a long acting, selective, reversible inhibitor of acetyl cholinesterase. One group of AA is the montanine-type, such as montanine, pancracine and others, which share a 5, 11-methanomorphanthridine core. Compared with other structural-types of AA, montanine-type alkaloids are predominantly present in plants in low concentrations, but some of them display promising biological properties, especially in vitro cytotoxic activity against some cancer cell lines.

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