International Journal of Pharmaceutical Sciences and Drug Analysis
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P-ISSN: 2788-9246, E-ISSN: 2788-9254
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International Journal of Pharmaceutical Sciences and Drug Analysis

2022, Vol. 2, Issue 1, Part A

Plasma kinetics profile of Nigerian indigenous dogs concurrently treated with diminazene aceturate and oxytetracycline long acting


Author(s): Onyeachonam FO, Onyeyili PA, Saganuwan AS and Agbo JO

Abstract: Concurrent administration of diminazene aceturate (DA) and oxytetracycline-long acting (oxyt-LA) to dogs often results in nervous signs and death of the animals, whereas oxytetracline-short acting is not associated with such negative effects. To verify the cause, one group comprising 6 dogs was treated with DA alone at dose of 3.5 mg/kg body weight, intravenously (IV) while a second group of 6 six dogs, was given DA intravenously, followed by Oxyt-LA, ten minutes later, at dose of 20 mg/kg, intra-muscularly. Blood was collected from each dog in the two groups, post treatment (PT) at: 0.25, 0.5, 1, 2, 3, 6, 9, 12, 24, 36, 48, 60, and 72 hours, for determination of plasma-DA concentrations. Plasma DA-concentrations in the dogs treated with DA plus oxyt–LA (16.75 ± 0.33; 12.85 ± 0.34; 10.29 ± 0.52; 8.55 ± 0.5; 6.89 ± 0.61 and 0.68 ± 0.07μg/ml) were significantly (p≤0.05) higher PT as compared with 12.95 ±.0.64; 9.66 ± 0.42; 6.46 ± 0.38; 4.56 ± 0.21; 2.83 ± 0.43 and 0.34 ± 0.05 of those treated with DA alone, respectively. AUC last (89.52 ± 5.07 mg/l/hr), AUC total (95.07 ± 5.43 mg/l/hr), AUMC (939.63 ± 109.94 mg.hr2/l) and T1/2α (2.15 ± 0.25 hr) of the DA -alone group were significantly (P≤0.05) lower than 141.96 6.60, 151.63 7.30, 1.17 0.19 and 2.00 0.35 of the DA plus oxyt-LA group respectively. Therefore, co-administration of the two drugs could reduce elimination rate of diminazene aceturate thereby enhancing its therapeutic efficacy.

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How to cite this article:
Onyeachonam FO, Onyeyili PA, Saganuwan AS, Agbo JO. Plasma kinetics profile of Nigerian indigenous dogs concurrently treated with diminazene aceturate and oxytetracycline long acting. Int J Pharm Sci Drug Anal 2022;2(1):15-19.
International Journal of Pharmaceutical Sciences and Drug Analysis