Author(s): Prashant Agnihotri and Nisar Ahmad Ganie

Abstract: Asiatic acid is a major triterpene obtained from plant C. asiatica. Asiatic acid has been reported to have antihyperglycemic activity in animal models. However, detailed and elaborated study depicting mode of action of this chemical has not been adequately described. The present study was designed to examine the antidiabetic effect of Asiatic acid (AA) in streptozotocin (STZ) induced diabetic rats. Diabetes was induced in male Wistar rats by a single intraperitoneal injection of STZ (40 mg/kg body weight). Diabetic rats show increased plasma glucose, reduced insulin level, relatively high amount of glycosylated haemoglobin and relatively less amount of plasma protein content. The antihyperglycemic effect of AA was compared with glibenclamide, a well-known antihyperglycemic drug. In conclusion, this study indicates that AA showed antihyperglycemic effect in experimental diabetic models.

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