2023, Vol. 3, Issue 1, Part A
Formulation and evaluation of nasal mucoadhesive microemulsion of sumatriptan succinateAuthor(s):
Mukul Pakhale, Jeevan Patel, Shabnam Khan, Ramakant Sharma and Dr. Rakesh PatelAbstract:
To formulate mucoadhesive microemulsion for nasal administration. The enhance rate of absorption, avoid first pass metabolism, reduce dose of drug and achieve systemic effect through the nasal route and evaluate the formulation for the following parameter, Clarity, pH Centrifugation, Particle size determination, Viscosity, Zeta potential, Electrophoretic mobility In-vitro mucoadhesion study, In-vitro drug diffusion study, Ex-vivo permeation study Histological study, Accelerated stability study, To evaluate optimized stability of formulation based on the above evaluation tests. The use of mucoadhesive systems as mucoadhesive microemulsion, provide a drug protection from enzymatic degradation and convert it in to gel and control the rate ofclearance from the nasal cavity. Sumatriptan succinate from this mucoadhesive microemulsion was found to be fairly rapid, because it converts into gel inside the nasal cavity and increase the residence time and bioavailability of the drug. The mucoadhesive microemulsion may be a useful approach for the rapid- onset delivery of sumatriptan succinate during the emergency treatment of acute attack of migraine. SS is a 5-HT 1 receptor agonist used in the treatment of migraine. It is generally given by oral or parenteral routes, however, a substantial proportion of patient suffer severe nausea or vomiting during their migraine attack, which make oral treatment unsatisfactory. Moreover, SS has previously been shown to have a low oral bioavailability in human volunteers (15%) due to high first pass metabolism justifiesa need of nasal drug delivery. Pages: 34-42 | Views: 21 | Downloads: 10Download Full Article: Click Here
How to cite this article:
Mukul Pakhale, Jeevan Patel, Shabnam Khan, Ramakant Sharma, Dr. Rakesh Patel. Formulation and evaluation of nasal mucoadhesive microemulsion of sumatriptan succinate. Int J Pharm Sci Drug Anal 2023;3(1):34-42.