International Journal of Pharmaceutical Sciences and Drug Analysis
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P-ISSN: 2788-9246, E-ISSN: 2788-9254
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2023, Vol. 3, Issue 1, Part B

A review on pathophysiology of breast cancer


Author(s): Dr. Jagannath Patro V, E Sheela, Mamilla Srinavya, Adepu Jyothika and Manda Sailaja

Abstract: In the majority of countries around the globe, breast cancer is the most commonly identified malignancy among women. Breast cancer develops due to DNA damage and genetic mutations that can be influenced by exposure to estrogen some times there will be an inheritance of DNA defects or pro-cancerous genes like BRCA1 and BRCA2. Breast cancer is a heterogenous disease with diverse, molecular, genetic, phenotypic and pathological changes. Many models of breast carcinogenesis have been suggested and phenotypic plasticity is exemplified by a distinctive phenotype called Epithelial-to-mesenchymal transition [EMT]. EMT programs may revert through mesenchymal-epithelial [MET] to the pervious phenotypic state before the induction of EMT program. The cells are protected from programmed cell death by different path ways like P13K/AKT pathway and another is RAS/MEK/ERK pathway.

Pages: 94-97 | Views: 42 | Downloads: 22

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How to cite this article:
Dr. Jagannath Patro V, E Sheela, Mamilla Srinavya, Adepu Jyothika, Manda Sailaja. A review on pathophysiology of breast cancer. Int J Pharm Sci Drug Anal 2023;3(1):94-97.
International Journal of Pharmaceutical Sciences and Drug Analysis
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