International Journal of Pharmaceutical Sciences and Drug Analysis
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P-ISSN: 2788-9246, E-ISSN: 2788-9254
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2023, Vol. 3, Issue 2, Part A

Genotoxicity by micronucleus assay of exfoliated oral buccal cells in cigarette smokers


Author(s): Sarab Dalaf Khalaf and Atyaf Talal Mahmood

Abstract: Smoking cigarettes can lead to a number of health issues or fatal diseases including cancer. The numerous lethal carcinogens found in cigarettes cause DNA damage in a variety of organs. The frequency and length of exposure directly correlate with this harm. Micronuclei arise primarily as a result of genetic damage to living cells. The micronucleus (MN), a nuclear body that can easily be seen in exfoliated buccal cells, is created when chromosomes break or segregate during cell division. This study was done to estimate the DNA damage in smokers' exfoliated buccal cells. So, utilizing MN assay of exfoliated buccal cells from nonsmokers (Comparison group) and smokers with respect to duration and frequency of use, the current study was conducted to assess the genetic damage. Two groups of people were taken, 50 for smokers, and 30 nonsmokers. Results were noted, In Controls and Smokers, the mean and variance of the percentage of nuclear abnormalities overall were, respectively. (25.967±0.681), (46.240±0.700*). The results of an independent sample t-test indicated a significant difference between the means of the two groups. Statistically significant results were seen for both smokers and controls.

Pages: 08-10 | Views: 299 | Downloads: 111

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International Journal of Pharmaceutical Sciences and Drug Analysis
How to cite this article:
Sarab Dalaf Khalaf, Atyaf Talal Mahmood. Genotoxicity by micronucleus assay of exfoliated oral buccal cells in cigarette smokers. Int J Pharm Sci Drug Anal 2023;3(2):08-10.
International Journal of Pharmaceutical Sciences and Drug Analysis
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