Author(s): Pham Nguyen Cuong, Nguyen Ngoc Vinh Bao, Luong Trung Nguyen, Nguyen Dao Thanh Tam, Pham Nguyen Bao and Tran Thi Ngoc Phuong

Abstract: BRAF mutations are rare, but these mutations can cause many serious health problems. BRAF mutations occur in colorectal cancer, thyroid cancer, melanoma, ovarian tumor, etc. Colorectal cancer with BRAF gene mutation at the V600E has a worse prognosis than those without mutation. Hue Central Hospital, using a Real-time PCR instrument of Diatech Pharmacogenetics Company, detected 2 of 62 cases of BRAF gene mutation at V600E with lymph node metastasis as soon as cancer was detected. The purpose of the article is to record data and review the literature to study more on this type of clinical disease.

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