2024, Vol. 4, Issue 1, Part A
Formulation, evaluation, and optimisation of bilayer floating tablet that contained repaglinide and glipizide
Author(s): Praveen Kumar Yadav, Jitendra Malik, Gyan Singh, G Pawan Kumar, Surendra Pratap Singh, Anadi Tiwari and Prachi Gupta
Abstract: Effective glycemic control is crucial in managing type 2 diabetes. This study aimed to develop a novel bilayer tablet formulation to provide both rapid onset and sustained release of antidiabetic agents. The Immediate-Release (IR) layer contained repaglinide for quick blood sugar lowering, while the floating bio adhesive Sustained-Release (SR) layer housed glipizide for prolonged therapeutic effect. This design aimed to improve patient compliance and optimize glycemic control. This study investigated the development and in-vivo evaluation of a novel floating tablet formulation for extended drug delivery. Barium sulfate tablets with varying concentrations were prepared and evaluated for their floating properties in vitro. Tablets containing 30% barium sulfate demonstrated optimal buoyancy and structural integrity. These (batch A6 and C2) were chosen for further in-vivo evaluation using X-ray imaging in Albino rabbits. The X-ray results confirmed successful floating of both batches (A6 and C2) in the rabbit stomach for over 8 hours. Additionally, batch C2 exhibited minimal positional change, suggesting potential mucoadhesive properties. This research highlights the potential of gastroprotective tablets for prolonged drug delivery via the oral route. By extending gastric residence time, these formulations can potentially improve drug bioavailability and overcome challenges associated with variable gastric emptying rates. Further investigation is required to optimize the formulation and fully understand its in-vivo performance.
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How to cite this article:
Praveen Kumar Yadav, Jitendra Malik, Gyan Singh, G Pawan Kumar, Surendra Pratap Singh, Anadi Tiwari, Prachi Gupta. Formulation, evaluation, and optimisation of bilayer floating tablet that contained repaglinide and glipizide. Int J Pharm Sci Drug Anal 2024;4(1):24-36.