International Journal of Pharmaceutical Sciences and Drug Analysis
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P-ISSN: 2788-9246, E-ISSN: 2788-9254
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2024, Vol. 4, Issue 1, Part A

Formulation and evaluation of anti-acne Emulgel of isotretinoin


Author(s): Chetna Malviya, Umesh Atneriya, Prajakta Shelke, Rahul Maskawade, Anubhav Shrivastav and Mohit Chaturvedi

Abstract: The object of presented work is to formulation of a topical emulgel of Isotretinoin for the treatment of mild to moderate acne, where systemic therapy is avoidable. Formulation of anti-acne emulgel of Isotretinoin using carbopol 934 as a gelling agent and tween 20, span 20 as some emulsifiers. For increase the permeation of the drug through skin and enhance its therapeutic activity by use propylene glycol as a penetration enhancer. The characterization of Isotretinoin drug sample was done using UV/visible spectrophotometric study at λmax 355nm, FTIR spectroscopy and melting point determination. All the observed data were comparable to the values report in literature. Preformulation study of Isotretinoin was performed, partition coefficient of the drug was found to be 5.6 (octanol/phosphate buffer). To rule out the physical incompatibility between the Isotretinoin and the excipients, blends of the drug and excipients were kept under varied temperature conditions for one month. The formulations were evaluated for their physical appearance, homogenecity, % drug content, pH, Spread ability, in vitro drug release and stability study. The pH of the formulation was found in the normal range 5.8-6.8, without produce any skin irritation, IE2 formulation showed highest spread ability 23.56 g.cm/sec, also have high percentage of drug content in IE2 formulation 92.02%. All formulations are transparent, homogeneous and have good consistency, alcoholic smell, free from stickiness and phase separation. IE1 emulgel formulation has highest viscosity 14500 cos. The in vitro release of prepared Isotretinoin emulgel have 80% of drug release and all the formulations are stable in 2-6 °C, 25 °C and 40 °C temperature. The topical anti acne emulgel of Isotretinoin was successfully formulated and evaluated for different parameters. The result indicate that the active component Isotretinoin is more effective when subjected in emulgel formulation and produces effective anti-acne activity in the management of nodulosystic acne vulgaris.

Pages: 59-65 | Views: 440 | Downloads: 280

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International Journal of Pharmaceutical Sciences and Drug Analysis
How to cite this article:
Chetna Malviya, Umesh Atneriya, Prajakta Shelke, Rahul Maskawade, Anubhav Shrivastav, Mohit Chaturvedi. Formulation and evaluation of anti-acne Emulgel of isotretinoin. Int J Pharm Sci Drug Anal 2024;4(1):59-65.
International Journal of Pharmaceutical Sciences and Drug Analysis
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