Author(s): Ritesh Kumar Singh and Ashvani Kumar

Abstract: Intragastric Floating Drug Delivery Systems represent a cutting-edge advancement in pharmacology, revolutionizing drug delivery by enhancing the gastric retention and bioavailability of medications. By capitalizing on buoyancy principles, Floating Drug Delivery Systems ensures prolonged drug release and improved absorption, particularly for drugs absorbed in the stomach or upper small intestine. This is achieved through the incorporation of effervescent components and low-density polymers, which enable Floating Drug Delivery Systems to float on gastric fluids, thereby maintaining optimal drug presence in the stomach for therapeutic effects. It can be classified into single-unit and multiple-unit systems, each offering unique advantages. Single-unit systems, such as hydrodynamically balanced systems and gas-generating systems, provide reduced dosing frequency and targeted drug delivery. On the other hand, multiple-unit systems, including floating beads and microspheres, offer benefits such as reduced risk of dose dumping and more uniform distribution throughout the stomach. Despite challenges related to maintaining appropriate buoyancy and formulation stability, Floating Drug Delivery Systems holds great promise for the treatment of various conditions, including peptic ulcers, gastroesophageal reflux disease, and Parkinson's disease. Additionally, Floating Drug Delivery Systems is well-suited for controlled drug release, offering a means to maintain therapeutic levels over an extended period, thereby minimizing side effects. Ongoing research endeavors are dedicated to optimizing Floating Drug Delivery Systems, with the ultimate goal of enhancing patient outcomes and advancing drug delivery technology. Through continuous refinement and innovation, Floating Drug Delivery Systems emerges as a valuable tool in modern pharmacotherapy, offering innovative solutions to improve medication efficacy and enhance patient quality of life.

Pages: 72-79 | Views: 262 | Downloads: 125

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