Author(s): Rajakarthikeyan U, Thamizhselvan S, M Sabareesh, Saranraj L, R Yuvhraj, A Anthony Jerome, Marannambi S, Karthik Raja R, N Vijayakumar and Sharan S

Abstract: Nanotechnology has revolutionized the pharmaceutical sciences by facilitating the creation of nanovesicular drug delivery vehicles like ethosomes, proniosomes, niosomes, and liposomes. Proniosomes emerge as the best of them, overcoming the issues faced by other vesicular carriers. Proniosomes are dry, freely flowing, nanoscale vesicular structures of powder or gel that contain pharmaceuticals and, upon hydration, generate multilamellar niosomal dispersion. They can also be used to improve the solubility, permeability, and bioavailability of a variety of drugs. Proniosomes can effectively deliver drugs through the transdermal route, achieving controlled release action and increased therapeutic effectiveness for a variety of diseases. Additionally, when proniosomes are applied topically, the skin's natural water content converts them into niosomes in real time. This study intends to explore proniosomes for various pharmaceutical applications in drug delivery via different routes, such as topical, transdermal, oral, parenteral, ocular, vaginal, nebulizer, and intranasal routes. It also intends to discuss various aspects of proniosomes, including merits, mechanism, types, components, preparation, characterization, drug release, market scenario, and future trends. These proniosome-derived niosomes are superior to other vesicular and conventional dosage forms and may provide a great, affordable alternative delivery method.

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