Author(s): Riya, Atul Kumar and Priyanka

Abstract: Diabetes mellitus, a chronic metabolic disorder, is characterized by chronic hyperglycaemia resulting from defects in insulin secretion, insulin action, or both. Insulin resistance, a key feature of Type 2 diabetes, arises from impaired insulin signalling, particularly at the insulin receptor level. Current treatments for diabetes often involve synthetic drugs, which may have adverse side effects or limited efficacy. In recent years, natural compounds derived from plants have garnered significant attention as potential alternatives for managing diabetes due to their diverse bioactive properties, including the ability to enhance insulin sensitivity. This research paper investigates the molecular interactions between selected natural compounds and insulin receptors through molecular docking techniques. Using in silico methods, we examine the binding affinities and key interactions of compounds such as quercetin, curcumin, and berberine with the insulin receptor, aiming to identify novel therapeutic agents that could improve glucose homeostasis. The findings from these molecular docking studies provide valuable insights into the potential role of natural compounds in modulating insulin receptor activity, offering a promising avenue for developing safer and more effective treatments for diabetes management.

Pages: 22-28 | Views: 19 | Downloads: 10

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