Author(s): Imad Noaman Shareef

Abstract: We investigated the protective role of thymoquinone (TQ) on isoprenaline caused myocardial infarction via electrocardiographic and biochemical adjustments. Methods: Subcutaneous (S.C.) injections of isoprenaline (85 mg/kg) were used to induce myocardial infarction in rats for two days in a row, separated by 24 hours. Thymoquinone was administered to rats in a single isoprenaline injection in the sixth and seventh days. At the conclusion, at the eighth day, biochemical and electrocardiographic alterations were tracked by experimental and management companies. Results: As warning signs and symptoms of oxidative strain, isoprenaline-intoxicated rats disclosed a significant change in electrocardiograph layout (i.e., ST, QTc, and HR) caused by conduction defects, increased levels of creatine phosphokinase isoenzyme-MB (CK-MB), prolonged infarction length, and myofibril disarray. Significantly, pretreatment with TQ prevented the metabolic changes and isoprenaline-induced ECG abnormalities. Conclusions: The current data indicates that TQ treatment significantly reduces the myocardial infarction in rats induced via isoprenaline.

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