Author(s): Aditya Pramana, Nurul Aisyah Rahman and Budi Santoso

Abstract: The present study investigates the application of non-destructive methods (NMDs) for assessing the integrity of bioactive compounds in fruit-based pharmaceutical products. The primary objective was to evaluate and compare the performance of Near-Infrared Spectroscopy (NIRS), Hyperspectral Imaging (HSI), and Raman Spectroscopy in analyzing key bioactives such as anthocyanins, vitamin C, and flavonoids in pomegranate, blueberry, and Indian gooseberry extracts. Calibration models were developed and validated using R² and RMSEP values, with Raman spectroscopy showing the highest accuracy and precision, followed by NIR and HSI. The spectral data obtained from each method were analyzed using chemometric tools, including Principal Component Analysis (PCA), which successfully distinguished between the different fruit extracts. The results indicated that Raman spectroscopy outperformed other NMDs in both quantitative and qualitative analysis of bioactives, making it the most reliable technique for quality control in fruit-based pharmaceutical formulations. The study demonstrates the potential of NMDs as a sustainable and efficient alternative to traditional destructive methods in the pharmaceutical industry. The integration of these techniques into routine production processes offers significant advantages, including reduced material wastage, real-time analysis, and improved decision-making capabilities.

Pages: 227-232 | Views: 133 | Downloads: 57

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