2025, Vol. 5, Issue 2, Part A

The main purpose of this study was to prepare and evaluate Liquid Crystal Emulsion.

The comparative evaluation of liquid crystal emulsions containing an API and herbal oil demonstrated that both formulations were physically stable and suitable for topical application, with zeta potential values of −53.3 mV (API) and −56.5 mV (herbal oil), indicating strong colloidal stability. However, the herbal oil-based emulsion showed slightly greater stability and better resistance to aggregation. Both emulsions maintained an optimal skin-compatible pH and exhibited well-defined lamellar liquid crystal structures under microscopy. While the API formulation had higher viscosity and uniform droplet distribution, the herbal oil emulsion excelled in sensory properties, offering a smoother texture and pleasant natural aroma. Most notably, the herbal oil formulation showed superior anti-aging activity by enhancing skin hydration, elasticity, and providing antioxidant protection. These findings suggest that the herbal oil-based liquid crystal emulsion is more stable and effective for cosmoceutical and anti-aging applications compared to the API-based formulation.