Author(s): Rajia Sultana Nijhu

Abstract: A literature review on pharmaceutical nanotechnology for the oral delivery of anticancer drugs was conducted as part of this project. Oral chemotherapy is a vital aspect of 21st-century medicine, offering potential improvements to traditional chemotherapy regimens and enhancing patients' quality of life. This study collected information on nanotechnology applications, advantages, methods, materials, and challenges from various online resources, including articles published from 2002 to 2023. The molecular mechanisms that form the gastrointestinal (GI) barrier are primarily related to efflux proteins such as P-glycoproteins (P-gp) located in epithelial membranes. While P-gp inhibitors like cyclosporine A can aid in oral chemotherapy, they may also weaken the immune system, leading to complications. Pharmaceutical nanotechnology seeks to address these drug delivery challenges and could transform how drugs are developed and administered. This review focuses on the issues associated with oral chemotherapy and presents nanotechnology-based solutions, including prodrugs, nanoemulsions, dendrimers, micelles, liposomes, solid lipid nanoparticles, and biodegradable polymer nanoparticles. Additionally, it provides evidence from in vitro and in vivo studies supporting the use of various nanocarriers for anticancer drug delivery. Overall, the review aims to discuss essential aspects of nanotechnology's role in the oral delivery of anticancer medications, highlighting both the potential benefits and the challenges that remain in this field.

DOI: 10.22271/27889246.2025.v5.i2a.128

Pages: 25-34 | Views: 98 | Downloads: 28

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