Author(s): Indhumathi K, Murugan S and Vetrichelvan T

Abstract: Three simple UV techniques have been developed to determine the dosage of Polmacoxib in both bulk and capsule form. Using a forced degradation study, the techniques include the zero, first order derivative, and area under the curve. The zero-order λmax of Polmacoxib is 316 nm. 256 nm was chosen as the wavelength for first order. The area under the curve was integrated between the wavelength ranges of 325 nm and 305 nm in this study. The area under the curve and zero order method for Polmacoxib in methanol were found to be linear between 5 and 25 µg/ml, while the first order method was found to be linear between 20 and 100 µg/ml. The correlation coefficients for the zero-order, first-order derivative, and area under the curve methods are 0.9999, 0.9998, and 0.9998, respectively, and they demonstrate strong linearity in the concentration range mentioned above.

Pages: 120-127 | Views: 73 | Downloads: 33

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