Author(s): Nirmala G, Murugan S and Vetrichelvan T

Abstract: In this study, a novel UV-spectrophotometric method was developed and validated for the quantitative estimation of Iguratimod in bulk and tablet formulations using zero-order and first-order derivative techniques. The method demonstrated simplicity, precision, and accuracy. A 10 μg/ml Iguratimod solution was prepared and scanned within the UV range of 200-400 nm. Quantification was performed at 258 nm for the zero-order and 270 nm for the first-order derivative method. Linearity was observed over 2-10 μg/ml (R² = 0.9997) for zero-order and 5-25 μg/mL (r² > 0.9998) for first-order methods. The percentage recovery ranged from 99.52% to 100.66%, confirming accuracy. The LOD and LOQ were 0.4553 and 1.3799 μg/mL (zero-order) and 0.9443 and 2.8615 μg/mL (first-order), respectively. The validated method proved reliable, efficient, and suitable for routine quality control and quantitative analysis of Iguratimod in pharmaceutical dosage forms.

Pages: 135-141 | Views: 77 | Downloads: 45

Download Full Article: Click Here